Endocrine Abstracts

Background and aims: Diabetic kidney disease (DKD) is a common microvascular complication that affects 40% of patients with diabetes mellitus (DM). Emerging evidence suggests a role for microRNAs (miRNAs) in the development of DKD. In this context, miR-15a-5p and miR-30e-5p have been shown to regulate the expression of the uncoupling protein 2, a mitochondrial protein that decreases reactive oxygen species (ROS) formation by mitochondria. Since ROS overproduction is a key cont...